In the world of mycology, few names resonate as deeply as Paul Stamets. A pioneer of mushroom cultivation and research, he is an avid proponent for the ecological and medicinal benefits of fungi. His lifelong journey in mycology has been one of exploration, innovation, and discovery, transforming our understanding of mushrooms and the profound impact they can have on the world around us.
A popular microdosing stack that has taken the psychedelic community by storm, the Stamets stack is a combination of three natural substances: psilocybin mushrooms, Lion’s Mane mushroom, and niacin. Each ingredient plays a distinct role in the stack, but when combined they offer compounded neurogenic effects that enhance cognitive function and promote emotional well-being. URL
Named after mycologist Paul Stamets, this blend is designed to support neuroplasticity and neural repair by boosting cellular health. It contains psilocybin, a powerful natural antidepressant and psychedelic substance that interacts with serotonin receptors in the brain to potentially alter mood, cognition, and emotion processing. It also supports the production of nerve growth factor (NGF), a protein essential for brain health and neurogenesis, which is the process of creating new neurons in the brain.
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The Lion’s Mane mushroom, Hericium erinaceus, in the Stamets stack contains compounds known as hericenones and erinacines that are thought to support the production of NGF. Like psilocybin, hericenones and erinacines inhibit monoamine oxidase, which means that they can help reduce the psychoactivity of psilocybin by blocking its breakdown in the body. Niacin, or Vitamin B3, is included in the stack to bolster psilocybin’s bioavailability by temporarily widening blood vessels, which results in a flushing sensation called the “niacin flush.” This enables more of the psilocybin and Lion’s Mane to be absorbed and distributed in the brain.